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Research articles

Io’s tidal response precludes a shallow magma ocean.

R. A. Jacobson
S. J. Bolton

Earliest modern human genomes constrain timing of Neanderthal admixture

Arev P. Sümer
Hélène Rougier
Johannes Krause

Aromatic ring-opening metathesis

Valeriia Hutskalova
Christof Sparr

Skin autonomous antibody production regulates host-microbiota interactions

Inta Gribonika
Victor I. Band
Yasmine Belkaid

Structures and mechanism of condensation in nonribosomal peptide synthesis

Angelos Pistofidis
Pengchen Ma
T. Martin Schmeing

The structure of apolipoprotein B100 from human low-density lipoprotein

Zachary T. Berndsen
C. Keith Cassidy

Structure and mechanism of the Zorya anti-phage defense system

Philipp F. Popp
Nicholas M. I. Taylor

Discovery and engineering of the antibody response to a prominent skin commensal

Djenet Bousbaine
Katherine D. Bauman
Michael A. Fischbach

Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours

A study reporting the results of a clinical trial co-administering the GDF-15-blocking antibody visugromab with the anti-PD-1 antibody nivolumab demonstrates that neutralizing GDF-15 can overcome resistance to immune checkpoint inhibition in cancer.

Ignacio Melero
Maria de Miguel Luken

Native DGC structure rationalizes muscular dystrophy-causing mutations

The detailed structure of the native dystrophin–glycoprotein complex provides mechanistic insights into mutations underlying muscular dystrophy.

Shiheng Liu
Tiantian Su
Z. Hong Zhou

Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia

A platform for mRNA lipid nanoparticle delivery to the placenta to treat pre-eclampsia is shown to improve fetal and maternal health in mice and has potential clinical applications in obstetric disorders and women’s health.

Kelsey L. Swingle
Alex G. Hamilton
Michael J. Mitchell

Self-organized patterning of crocodile head scales by compressive folding

Crocodile head scales self-organize through purely mechanical compressive skin folding rather than a patterning process controlled by gene interactions.

Gabriel N. Santos-Durán
Rory L. Cooper
Michel C. Milinkovitch

Large global-scale vegetation sensitivity to daily rainfall variability

Satellite data and field observations show that global annual-scale vegetation indices are sensitive to the daily frequency and intensity of rainfall, independent of the total amount of rainfall per year.

Andrew F. Feldman
Alexandra G. Konings
Benjamin Poulter

Structure of apolipoprotein B100 bound to the low-density lipoprotein receptor

Cryo-electron microscopy structures of apolipoprotein B100 (apoB100) in complex with the LDL receptor (LDLR) provide insight into binding interfaces and explain how mutations in apoB100 or in LDLR can give rise to familial hypercholesterolaemia.

Mart Reimund
Altaira D. Dearborn
Joseph Marcotrigiano

Strong-field quantum control in the extreme ultraviolet domain using pulse shaping

Ultrafast quantum control of helium atoms is obtained by shaping the extreme ultraviolet pulses generated by a seeded free-electron laser.

Fabian Richter
Ulf Saalmann
Lukas Bruder

Structure and assembly of the dystrophin glycoprotein complex

A structural study of native dystrophin glycoprotein complex from mouse skeletal muscle reveals an extended tower-like architecture that provides multiple binding sites on both sides of the membrane for signalling and effector molecules, reshaping our understanding of how the complex is assembled.

Jianping Wu

Continuous collective analysis of chemical reactions

Mass spectrometry fragmentation patterns define analytical barcodes for the rapid, quantitative analysis of high-throughput chemical synthesis experiments.

Daniel J. Blair

Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase

The development of a first-in-class non-covalent small-molecule inhibitor of SARS-CoV-2 replication that targets the viral guanine-N7 methyltransferase NSP14 is reported.

Cindy Meyer
Aitor Garzia
Thomas Tuschl

Crosslinking intermodular condensation in non-ribosomal peptide biosynthesis

Structural studies of tyrocidine synthetase using site-selective crosslinking probes to link condensation domains with carrier protein substrates define key interactions and molecular mechanisms of non-ribosomal protein synthesis.